個人介紹

腦病個性化防治跨學科研究所所長; 中醫藥調控腦-外周穩态與大健康粵港澳聯合實驗室主任; 博士生導師

職稱：教授

研究方向： 經典名方個性化防治抑郁症，癡呆症的現代機制研究與應用轉化

電子郵箱：chengang@jnu.edu.cn

Name: Chen Gang

Director of the Interdisciplinary Institute for Personalized Medicine on Brain Disorders; Director of the GHM Joint Laboratory of Traditional Chinese Medicine on Brain-Peripheral Homeostasis and Comprehensive Health

Title: Professor

Research Focus: the mechanic and translational research on personalized prevention and treatment of depression and dementia by using Traditional Chinese Medicine, particularly Classical Herbal Formulas

Email：chengang@jnu.edu.cn

獲美國羅格斯大學心理學博士。重點從事經典名方（如越鞠丸，好忘方等）優勢性抗抑郁抗癡呆的現代機理與複方物質基礎與轉化研究，主持國家重點研發計劃等多項國家及省級重點課題，一作/通訊作者發表中英文雜志論文各40餘篇，主持或報告海外學術會議10餘場。任中國生理學會中醫藥與腦穩态調控專委會創會主任委員，中華中醫藥學會中基分會常務理事，國際腦與行為遺傳學會常務理事等。獲省特聘教授，省雙創團隊領軍人才等稱号。

Professor Chen received a Ph.D. in Psychology from Rutgers University in the United States. His research focuses on  the current molecular and system mechanisms and compound substance basis of classical Chinese herbal formulas (such as Yueju Pill and Haowang Formula)  in combating depression and dementia like Alzheimer’s Disease, with their advantages being scientifically revealed. He has been awarded with multiple national and provincial key research project grants, including the National Key Research and Development Program. He has published over 40 research papers in both Chinese and English journals as the first author or corresponding author, and presented at more than 10 international academic conferences. He has served as the Founding Chairman of the Chinese Physiological Society’s Committee on Traditional Chinese Medicine and Brain Homeostasis Regulation, executive council member of the Committee on Theory Foundation of Traditional Chinese Medicine of Chinese Association of Traditional Chinese Medicine, and member-at-large of the International Society of Brain and Behavior Genetics. He has been honored as a Distinguished Provincial Professor and the Leader of a provincial Innovation and Entrepreneurship Talent Team.

科研成果

陳剛教授自2012年以來，首次揭示中藥越鞠丸快速抗抑郁效用，特定機制及相互作用物質基礎。以該研究為代表，針對現有主流醫學在治療抑郁症，老年癡呆等嚴重腦病上存在的明顯問題，通過深入系統發掘特定經典名方的潛在優勢，對其功效的個性化差異及特定機理進行創新性闡釋，并探索出基于複方核心機制靶标科學揭示其靶向協同成分的複方物質基礎的新研究方法，提出并建立中醫證候與疾病的共易感性及其研究模型，揭示中醫藥辨證論治的科學内涵，并創制了新的抑郁症癡呆症的預防和治療手段。

①代表性課題：

2022-2024   科技部戰略性科技創新合作重點專項“中藥複方有效成分協同激活主效靶點PACAP介導快速持久抗抑郁機制與應用研究” 200萬

2022-2025   國家自然科學基金面上項目“海馬齒狀回GLP-1-PACAP信号級聯調控越鞠丸快速抗抑郁機制研究”55萬

2019-2022   國家自然科學基金面上項目（動物模型）“基于抑郁症和氣虛證應激共易感性的病證結合動物模型研究” 81萬

2017-2019   江蘇雙創團隊項目主持人  300萬

②代表性論文(Representative papers)：

Zhang H, Sun Y, Yau SY, Zhou Y, Song X, Zhang HT, Zhu B, Wu H*, Chen G*. Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up-regulating hippocampal PACAP signaling. Br J Pharmacol. 2022 Mar 31. doi: 10.1111/bph.15847. Epub ahead of print. PMID: 35362097.

Zhang Y, Cui B, Wang T, Lu Y, Chen Z, Zou Z, Miao J, Zhao X, Yuan Y, Wang H*, Chen G*. Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy. Front Behav Neurosci. 2021 Oct 27;15:712445. doi: 10.3389/fnbeh.2021.712445. PMID: 34776888; PMCID: PMC8578865.

Tang J, Lu L, Wang Q, Liu H, Xue W, Zhou T, Xu L, Wang K, Wu D, Wei F, Tao W, Chen G*. Crocin Reverses Depression-Like Behavior in Parkinson Disease Mice via VTA-mPFC Pathway. Mol Neurobiol. 2020 Jul;57(7):3158-3170.

Chen G*, Xue WD, Zhu J 2018 Full genetic analysis for genome-wide association study of Fangji: a powerful approach for effectively dissecting the molecular architecture of personalized traditional Chinese medicine. Acta Pharmacol Sin. 2018 Feb 8. doi: 10.1038/aps.2017.137

Wu R, Zhang H, Xue W,  Zou ZL, Lu C,  Xia B, Wang W, Chen G* 2016 Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness. Prog Neuropsychopharmacol Biol Psychiatry. 28;73:11-18

Tang J, Xue W, Xia B, Ren L, Tao W, Chen C, Zhang H, Wu R, Wang Q, Wu H, Duan J, Chen G*. 2015 Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice. Sci Rep. 2015 28;5:13573.

Xue W, Zhou X, Yi N, Jiang L, Tao W, Wu R, Wang D, Jiang J, Ge X, Wang Y, Wu H, Chen G*. 2013. Yueju pill rapidly induces antidepressant-like effects and acutely enhances BDNF expression in mouse brain. Evidence-Based Complementary and Alternative Medicine. 2013:184367

王省，陳剛，試論樞轉少陽與快速抗抑郁，中醫雜志，2017年第58卷第2期：174-176

王旭東,喬明琦,張樟進,陳剛,陳家旭,圖娅.中醫藥治療抑郁症的研究進展.南京中醫藥大學學報,2016,32(1):93-96.

獲獎及榮譽

1、江蘇省特聘教授

2、江蘇省雙創人才

3、江蘇省雙創團隊領軍人才

江蘇省中醫藥領軍人才

2022廣東省科技進步二等獎（排名第四）

學術兼職

中國生理學會中醫藥與腦穩态調控專委會首任主任委員及中國生理學會理事；

中華中醫藥學會中醫基礎理論分會常務理事；

世界中醫藥聯合會李時珍醫藥應用與研究專業委員會和心身醫學專業委員會常務理事；

國際行為和神經遺傳學會（IBANGs）執行理事（Member-at-large）兼會員委員會主席（2020-2023）；

粵港澳腦病中醫藥産學研創新技術聯盟副理事長兼秘書長

廣東省精準醫學會阿爾茲海默症分會副主委；

美國神經科學學會（SFN）會員等；

《腦，行為，免疫-整合》（《Brain，Behavior， Immunity-Integrative》）雜志副主編；

《環球中醫藥》雜志編輯等