個人介紹

姓名：段文君

職稱：教授

研究方向：中藥及天然産物抗帕金森病的作用和機制

電子郵箱：duanwj@jnu.edu.cn

本人自從業十餘年至今，主要研究方向是中藥藥理學，研究内容是中藥及天然産物抗帕金森病的作用和機制，解析帕金森病緻病因素和原理，尋找靶向治療帕金森病的活性物質，開發中西醫結合治療帕金森病的用藥策略，并以此為研究内容主持廣東省自然科學傑出青年項目、國家自然科學面上項目、國家自然科學青年項目等多個科研項目，專利申請獲授權4項，在The Journal of Clinical Investigation、Cell Death & Differentiation、Science China Life Sciences、Redox Biology、Pharmacological Research、Aging Cell等期刊發表多篇高水平SCI論文。

教學/科研成果

代表性論文：

1.  Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. Jie Sun1, Xiao-Min Lin1, Dan-Hua Lu1, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan* (本人, 通訊作者), Gen-Long Jiao*, Li Zhang*, Rong-Rong He*. The Journal of Clinical Investigation. 2023, 133(10):e165228. Doi: 10.1172/JCI165228.

2.  Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2. Xiang Luo1, Hai-Biao Gong1, Hua-Ying Gao1, Yan-Ping Wu, Wan-Yang Sun, Zheng-Qiu Li, Guan Wang, Bo Liu, Lei Liang, Hiroshi Kurihara, Wen-Jun Duan* (本人, 通訊作者), Yi-Fang Li*, Rong-Rong He*. Cell Death & Differentiation. 2021, 28(6):1971-1989. Doi: 10.1038/s41418-020-00719-2. 入選“2021年度中醫藥十大學術進展”.

3.  Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development. Jie Niu1, Xin Wan1, Gui-Yuan Yu1, Shan Jiang1, Ruo-Nan Yi, Yan-Ping Wu, Shu-Hua Ouyang, Lei Liang, Hiroshi Kurihara, Wan-Yang Sun, Xiao-Feng Zhu, Rong-Hua Zhang, Yun-Feng Cao, Jian-Bo He*, Wen-Jun Duan* (本人, 通訊作者), Yi-Fang Li*, Rong-Rong He*. Redox Biology, 2022, 56:102437. Doi: 10.1016/j.redox.2022.102437.

4.GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS. Long-Fang Tu, Tian-Ze Zhang, Yang-Fan Zhou, Qing-Qing Zhou, Hai-Biao Gong, Lei Liang, Lin-Na Hai, Nan-Xin You, Yang Su, Yong-Jun Chen, Xu-Kai Mo, Chang-Zheng Shi, Liang-Ping Luo, Wan-Yang Sun, Wen-Jun Duan* (本人, 通訊作者), Hiroshi Kurihara, Yi-Fang Li*, Rong-Rong He*. Journal of Advanced Research. 2023, 43:205-218. Doi: 10.1016/j.jare.2022.02.016.

5.Cuproptosis: copper-induced regulated cell death. Wen-Jun Duan (本人, 第一作者), Rong-Rong He*. SCIENCE CHINA Life Sciences, 2022, 65:1680-1682. Doi: 10.1007/s11427-022-2106-6.

6.  ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis. Kun Li, Meng Wang, Zi-Han Huang, Min Wang, Wan-Yang Sun, Hiroshi Kurihara, Rui-Ting Huang, Rong Wang, Feng Huang, Lei Liang*, Yi- Fang Li*, Wen-Jun Duan* (本人, 通訊作者), Rong-Rong He*. Pharmacological Research. 2023, 29;193:106779. Doi: 10.1016/j.phrs.2023.106779.

7.  Autophagy-dependent removal of alpha-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease. Yu-Lin Guo1, Wen-Jun Duan1 (本人，并列第一), Dan-Hua Lu, Xiao-Hui Ma, Xiao-Xiao Li, Zhao Li, Wei Bi, Hiroshi Kurihara, Hai-Zhi Liu, Yi-Fang Li*, Rong-Rong He*. Acta Pharmacologica Sinica. 2021, 42(4):518-528. Doi: 10.1038/s41401-020-0454-y.

8.  Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation. Wen-Jun Duan1 (本人, 第一作者), Lei Liang1, Ming-Hai Pan, Dan-Hua Lu, Ting-Mei Wang, Shan-Bing Li, Han-Bing Zhong, Xuan-Jun Yang, Yan Cheng, Bo Liu, Wei-Xi Li, Hiroshi Kurihara, Wei Bi*, Yi-Fang Li*, Rong-Rong He*. Phytomedicine. 2020, 77:153281. Doi: 10.1016/j.phymed.2020.153281.

9.  Autophagy is involved in the effects of resveratrol on prevention of splenocyte apoptosis caused by oxidative stress in restrained mice. Wen-Jun Duan (本人, 第一作者), Fang-Lan Liu, Rong-Rong He*, Wei-Lin Yuan, Yi-Fang Li, Bun Tsoi, Wei-Wei Su, Xin-Sheng Yao, Hiroshi Kurihara*. Molecular Nutrition & Food Research, 2013, 57(7): 1145-1157. Doi: 10.1002/mnfr.201200662.

10. Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation. Ying-Nan Jiang, Yong-Zhi Guo, Dan-Hua Lu, Ming-Hai Pan, Hai-Zhi Liu, Gen-Long Jiao, Wei Bi, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan* (本人, 通訊作者), Rong-Rong He*, Xin-Sheng Yao*. Journal of Ethnopharmacology. 2020, 256:112824. Doi: 10.1016/j.jep.2020.112824.

11.磷脂重塑與帕金森病. 王萌, 栗原博, 李怡芳, 段文君* (本人, 通訊作者), 何蓉蓉. 藥學學報. 2022: 1-16. Doi: 10.16438/j.0513-4870.2022-0294. 北大核心/CSCD.

12.      帕金森病理機制常談常新:多巴胺能神經元的氧化性死亡——ferroptosis和oxytosis. 段文君 (本人, 第一作者), 李怡芳, 栗原博, 何蓉蓉*. 世界科學技術—中醫藥現代, 2018, 20(6): 823-833. Doi: 10.11842/wst.2018.06.001. 北大核心/CSCD.

13.      Neuroprotective effect of paeoniflorin on okadaic acid-induced tau hyperphosphorylation via calpain/Akt/GSK-3β pathway in SH-SY5Y cells. Xiao-Hui Ma1, Wen-Jun Duan1 (本人, 并列第一), You-Sheng Mo, Jun-Li Chen, Shi Li, Wei Zhao, Lei Yang, Sui-Qing Mi, Xin-Liang Mao, Hong Wang*, Qi Wang*. Brain Research. 2018, 1690:1-11. Doi: 10.1016/j.brainres.2018.03.022.

14.      Ferulic acid attenuates brain microvascular endothelial cells damage caused by oxygen-glucose deprivation via punctate-mitochondria-dependent mitophagy. Jun-Li Chen1, Wen-Jun Duan1 (本人, 并列第一), Si Luo, Shi Li, Xiao-Hui Ma, Bo-Nan Hou, Shu-Yi Cheng, Shu-Huan Fang, Qi Wang, Shui-Qing Huang, Yun-Bo Chen*. Brain Research. 2017, 1666:17-26. Doi: 10.1016/j.brainres.2017.04.006.

15.      Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway. Wenjun Duan (本人, 第一作者), Xiaoying Jin, Qisheng Li, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Journal of Pharmacological Sciences. 2010, 113(1):48-56. Doi: 10.1254/jphs.09315fp.

16.      Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways. Wen-Jun Duan (本人, 第一作者), Qi-Sheng Li, Ming-Yu Xia, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Biological & Pharmaceutical Bulletin, 2010, 34(1): 47-53. Doi: 10.1248/bpb.34.47.

17.      Silibinin activated ROS-p38-NF-κB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells. Wen-Jun Duan (本人, 第一作者), Qi-Sheng Li, Ming-Yu Xia, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Journal of Asian Natural Products Research, 2010, 13(1): 27~35. Doi: 10.1080/10286020.2010.540757.

18.      ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage. Xiao-Hui Ma, Jiang-Han-Zi Liu, Chun-Yu Liu, Wan-Yang Sun, Wen-Jun Duan (本人), Guan Wang, Hiroshi Kurihara, Rong-Rong He*, Yi-Fang Li*, Yang Chen*, Hongcai Shang*. Signal transduction and targeted therapy. 2022, 7(1):288. Doi: 10.1038/s41392-022-01090-z.

19.      Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Yue-Hong Zhang1, Yi-Fang Li1, Yongjin Wang1, Li Tan, Zhi-Qin Cao, Chao Xie, Guo Xie, Hai-Biao Gong, Wan-Yang Sun, Shu-Hua Ouyang, Wen-Jun Duan (本人), Xiaoyun Lu, Ke Ding, Hiroshi Kurihara, Dan Hu*, Zhi-Min Zhang*, Ikuro Abe*, Rong-Rong He*. Nature Communications. 2020, 19;11(1):1473. Doi: 10.1038/s41467-020-15324-7.

20.      Phospholipase iPLA(2)beta averts ferroptosis by eliminating a redox lipid death signal. Wan-Yang Sun Vladimir A Tyurin, Karolina Mikulska-Ruminska, Indira H Shrivastava, Tamil S Anthonymuthu, Yu-Jia Zhai, Ming-Hai Pan, Hai-Biao Gong, Dan-Hua Lu, Jie Sun, Wen-Jun Duan (本人), Sergey Korolev, Andrey Y Abramov, Plamena R Angelova, Ian Miller, Ofer Beharier, Gao-Wei Mao, Haider H Dar, Alexandr A Kapralov, Andrew A Amoscato, Teresa G Hastings, Timothy J Greenamyre, Charleen T Chu, Yoel Sadovsky, Ivet Bahar, Hülya Bayır, Yulia Y Tyurina*, Rong-Rong He*, Valerian E Kagan*. Nature Chemical Biology. 2021, 17(4):465-476. Doi: 10.1038/s41589-020-00734-x. 入選“2021年度中醫藥十大學術進展”.

學術兼職

1. 廣東省藥理學會内分泌代謝病藥理專業委員會常務委員

2. 廣東省中醫藥學會網絡藥理學專業委員會第一屆委員會委員

3. 廣東省藥理學會抗炎免疫藥理專業委員會委員