個人介紹

姓名： 姚偉

職稱：講師

研究方向：神經精神疾病發病機制及治療藥物研究

電子郵箱：weiyao@jnu.edu.cn

個人簡介：（限200字）

講師，醫學博士，碩士生導師。2017年4月畢業于日本千葉大學醫學院神經科學專業，獲得博士學位，博士畢業後就職于日本東京醫科齒科大學神經内科，從事助理研究員，主要研究阿爾茨海默病發病機制以及新藥研發相關基礎和臨床工作。2019年12月進入太阳集团1088vip工作。主要從事抑郁症發病機制、中藥及其有效活性成分防治抑郁症以及潛在治療藥物的研發。相關研究成果在Molecular Psychiatry、Translational Psychiatry、Molecular Therapy Nucleic Acids、Aging cell等國際高水平雜志發表SCI論文34篇，其中以（共）第一/通訊作者發表SCI論文12篇，h-index為27。主持國家級項目和省級課題各1項。主講《醫學科研方法概論》本科課程。

教學/科研成果

1. Lin Z, Huang L, Cao Q, Luo H, Yao W*, Zhang JC*. Inhibition of abnormal C/EBPβ/α-Syn signaling pathway through activation of Nrf2 ameliorates Parkinson's disease-like pathology. Aging cell. 2023, 23: e13958.

2. Luo H, Zhang C, He L, Lin Z, Zhang JC, Qi Q*, Chen JX*, Yao W*. 18β‐glycyrrhetinic acid ameliorates MPTP‐induced neurotoxicity in mice through activation of microglial anti‐inflammatory phenotype.Psychopharmacology (Berl). 2023, 240(9):1947-1961.

3. He L#, Zheng Y#, Huang L#, Ye J, Ye Y, Luo H, Chen X, Yao W*, Chen J*, Zhang JC*. Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice. Transl Psychiatry. 2022,12(1): 459.

4.Zhang JC*, Yao W, and Hashimoto K*. Arketamine, a new rapid-acting antidepressant: A historical review and future directions. Neuropharmacology. 2022. 218:109219.

5.Cao QQ #, Luo SL#, Yao W#, Qu YG, Wang NB, Hong J, Murayama S, Zhang ZT, Chen JX, Hashimoto K*, Qi Qi*, and Zhang JC*. Suppression of abnormal a-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology. Molecular Therapy Nucleic Acids. 2022. 29:1-15.

6. Huang LX#, He LJ#, Ma RJ#, Ding WZ, Zhou C, Lin S, Zhang JC, Chen JX* and Yao W*. The role of MeCP2 and the BDNF/TrkB signaling pathway in the stress resilience of mice subjected to CSDS. Psychopharmacology (Berl). 2022. 239(9):2921-2929.

7. Yao W#, Cao QQ#, Luo SL#, He LJ, Yang C, Chen JX, Qi Q*, Hashimoto K*, and Zhang JC*. Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine, Molecular Psychiatry. 2022, 27(3): 1618–1629.

8. Yao W#; Lin S#; Su J; Cao QQ; Chen YY; Chen JX; Zhang ZT; Hashimoto K*; Qi Q*; Zhang JC*. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents, Transl Psychiatry. 2021; 11: 140.

9. Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K. Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression. Eur J Pharmacol. 2016, pii: S0014-2999(16)30677-X.

10. Yao W, Zhang JC, Dong C, Zhuang C, Hirota S, Inanaga K, Hashimoto K. Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration. Pharmacol Biochem Behav 2015, 3(136):7-12

學術兼職

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